The upper-airway microbiota and loss of asthma control among asthmatic children

Yanjiao Zhou, Daniel Jackson, Leonard B. Bacharier, David Mauger, Homer Boushey, Mario Castro, Juliana Durack, Yvonne Huang, Robert F. Lemanske, Gregory A. Storch, George M. Weinstock, Kristine Wylie, Ronina Covar, Anne M. Fitzpatrick, Wanda Phipatanakul, Rachel G. Robison and Avraham Beigelman ()
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Yanjiao Zhou: University of Connecticut
Daniel Jackson: University of Wisconsin School of Medicine and Public Health
Leonard B. Bacharier: Washington University School of Medicine
David Mauger: Penn State University
Homer Boushey: University of California
Mario Castro: Washington University School of Medicine
Juliana Durack: University of California
Yvonne Huang: University of Michigan
Robert F. Lemanske: University of Wisconsin School of Medicine and Public Health
Gregory A. Storch: Washington University School of Medicine
George M. Weinstock: The Jackson Laboratory for Genomic Medicine
Kristine Wylie: Washington University School of Medicine
Ronina Covar: National Jewish Health
Anne M. Fitzpatrick: Emory University
Wanda Phipatanakul: Harvard Medical School
Rachel G. Robison: Ann and Robert H Lurie Children’s Hospital of Chicago
Avraham Beigelman: Washington University School of Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract The airway microbiome has an important role in asthma pathophysiology. However, little is known on the relationships between the airway microbiome of asthmatic children, loss of asthma control, and severe exacerbations. Here we report that the microbiota’s dynamic patterns and compositions are related to asthma exacerbations. We collected nasal blow samples (n = 319) longitudinally during a clinical trial at 2 time-points within one year: randomization when asthma is under control, and at time of early loss of asthma control (yellow zone (YZ)). We report that participants whose microbiota was dominated by the commensal Corynebacterium + Dolosigranulum cluster at RD experience the lowest rates of YZs (p = 0.005) and have longer time to develop at least 2 episodes of YZ (p = 0.03). The airway microbiota have changed from randomization to YZ. A switch from the Corynebacterium + Dolosigranulum cluster at randomization to the Moraxella- cluster at YZ poses the highest risk of severe asthma exacerbation (p = 0.04). Corynebacterium’s relative abundance at YZ is inversely associated with severe exacerbation (p = 0.002).

Date: 2019
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DOI: 10.1038/s41467-019-13698-x

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