Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation

G. Torromino, L. Autore, V. Khalil, V. Mastrorilli, M. Griguoli, A. Pignataro, E. Centofante, G. M. Biasini, V. De Turris, M. Ammassari-Teule, A. Rinaldi and A. Mele ()
Additional contact information
G. Torromino: Sapienza University of Rome
L. Autore: Sapienza University of Rome
V. Khalil: Sapienza University of Rome
V. Mastrorilli: Sapienza University of Rome
M. Griguoli: European Brain Research Institute (EBRI)
A. Pignataro: CNR - National Research Council, Institute of Translational Pharmacology
E. Centofante: Sapienza University of Rome
G. M. Biasini: Sapienza University of Rome
V. De Turris: Istituto Italiano di Tecnologia (IIT)
M. Ammassari-Teule: IRCCS Santa Lucia Foundation
A. Rinaldi: Sapienza University of Rome
A. Mele: Sapienza University of Rome

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum–ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-13703-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13703-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-13703-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().