Relationship between gut microbiota and circulating metabolites in population-based cohorts

Dina Vojinovic (), Djawad Radjabzadeh, Alexander Kurilshikov, Najaf Amin, Cisca Wijmenga, Lude Franke, M. Arfan Ikram, Andre G. Uitterlinden, Alexandra Zhernakova, Jingyuan Fu, Robert Kraaij and Cornelia M. van Duijn ()
Additional contact information
Dina Vojinovic: University Medical Center
Djawad Radjabzadeh: University Medical Center
Alexander Kurilshikov: University of Groningen, University Medical Center Groningen, Department of Genetics
Najaf Amin: University Medical Center
Cisca Wijmenga: University of Groningen, University Medical Center Groningen, Department of Genetics
Lude Franke: University of Groningen, University Medical Center Groningen, Department of Genetics
M. Arfan Ikram: University Medical Center
Andre G. Uitterlinden: University Medical Center
Alexandra Zhernakova: University of Groningen, University Medical Center Groningen, Department of Genetics
Jingyuan Fu: University of Groningen, University Medical Center Groningen, Department of Genetics
Robert Kraaij: University Medical Center
Cornelia M. van Duijn: University Medical Center

Nature Communications, 2019, vol. 10, issue 1, 1-7

Abstract: Abstract Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut microbiota on circulating metabolites measured by Nuclear Magnetic Resonance technology in 2309 individuals from the Rotterdam Study and the LifeLines-DEEP cohort. We assess the relationship between gut microbiota and metabolites by linear regression analysis while adjusting for age, sex, body-mass index, technical covariates, medication use, and multiple testing. We report an association of 32 microbial families and genera with very-low-density and high-density subfractions, serum lipid measures, glycolysis-related metabolites, ketone bodies, amino acids, and acute-phase reaction markers. These observations provide insights into the role of microbiota in host metabolism and support the potential of gut microbiota as a target for therapeutic and preventive interventions.

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13721-1

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DOI: 10.1038/s41467-019-13721-1

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