Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

Kazuya Ono, James Keller, Omar López Ramírez, Antonia González Garrido, Omid A. Zobeiri, Hui Ho Vanessa Chang, Sarath Vijayakumar, Andrianna Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock and Doris K. Wu ()
Additional contact information
Kazuya Ono: National Institutes of Health
James Keller: National Institutes of Health
Omar López Ramírez: University of Chicago
Antonia González Garrido: University of Chicago
Omid A. Zobeiri: Department of Physiology McGill University
Hui Ho Vanessa Chang: Department of Physiology McGill University
Sarath Vijayakumar: University of Nebraska-Lincoln
Andrianna Ayiotis: Johns Hopkins University School of Medicine
Gregg Duester: Stanford Burnham Prebys Medical Discovery Institutes
Charles C. Della Santina: Johns Hopkins University School of Medicine
Sherri M. Jones: University of Nebraska-Lincoln
Kathleen E. Cullen: Johns Hopkins University School of Medicine
Ruth Anne Eatock: University of Chicago
Doris K. Wu: National Institutes of Health

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Each vestibular sensory epithelium in the inner ear is divided morphologically and physiologically into two zones, called the striola and extrastriola in otolith organ maculae, and the central and peripheral zones in semicircular canal cristae. We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). In Cyp26b1 conditional knockout mice, formation of striolar/central zones is compromised, such that they resemble extrastriolar/peripheral zones in multiple features. Mutants have deficient vestibular evoked potential (VsEP) responses to jerk stimuli, head tremor and deficits in balance beam tests that are consistent with abnormal vestibular input, but normal vestibulo-ocular reflexes and apparently normal motor performance during swimming. Thus, degradation of RA during embryogenesis is required for formation of highly specialized regions of the vestibular sensory epithelia with specific functions in detecting head motions.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-13710-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13710-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-13710-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().