Transmission of tauopathy strains is independent of their isoform composition

Zhuohao He (), Jennifer D. McBride, Hong Xu, Lakshmi Changolkar, Soo-jung Kim, Bin Zhang, Sneha Narasimhan, Garrett S. Gibbons, Jing L. Guo, Michael Kozak, Gerard D. Schellenberg, John Q. Trojanowski and Virginia M. -Y. Lee ()
Additional contact information
Zhuohao He: University of Pennsylvania School of Medicine
Jennifer D. McBride: University of Pennsylvania School of Medicine
Hong Xu: University of Pennsylvania School of Medicine
Lakshmi Changolkar: University of Pennsylvania School of Medicine
Soo-jung Kim: University of Pennsylvania School of Medicine
Bin Zhang: University of Pennsylvania School of Medicine
Sneha Narasimhan: University of Pennsylvania School of Medicine
Garrett S. Gibbons: University of Pennsylvania School of Medicine
Jing L. Guo: University of Pennsylvania School of Medicine
Michael Kozak: University of Pennsylvania School of Medicine
Gerard D. Schellenberg: University of Pennsylvania School of Medicine
John Q. Trojanowski: University of Pennsylvania School of Medicine
Virginia M. -Y. Lee: University of Pennsylvania School of Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-18

Abstract: Abstract The deposition of pathological tau is a common feature in several neurodegenerative tauopathies. Although equal ratios of tau isoforms with 3 (3R) and 4 (4R) microtubule-binding repeats are expressed in the adult human brain, the pathological tau from different tauopathies have distinct isoform compositions and cell type specificities. The underlying mechanisms of tauopathies are unknown, partially due to the lack of proper models. Here, we generate a new transgenic mouse line expressing equal ratios of 3R and 4R human tau isoforms (6hTau mice). Intracerebral injections of distinct human tauopathy brain-derived tau strains into 6hTau mice recapitulate the deposition of pathological tau with distinct tau isoform compositions and cell type specificities as in human tauopathies. Moreover, through in vivo propagation of these tau strains among different mouse lines, we demonstrate that the transmission of distinct tau strains is independent of strain isoform compositions, but instead intrinsic to unique pathological conformations.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-13787-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13787-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-13787-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().