Image-guided neural activity manipulation with a paramagnetic drug

Sarah Bricault, Ali Barandov, Peter Harvey, Elizabeth DeTienne, Aviad Hai and Alan Jasanoff ()
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Sarah Bricault: Massachusetts Institute of Technology
Ali Barandov: Massachusetts Institute of Technology
Peter Harvey: Massachusetts Institute of Technology
Elizabeth DeTienne: Massachusetts Institute of Technology
Aviad Hai: Massachusetts Institute of Technology
Alan Jasanoff: Massachusetts Institute of Technology

Nature Communications, 2020, vol. 11, issue 1, 1-6

Abstract: Abstract Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.

Date: 2020
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DOI: 10.1038/s41467-019-13933-5

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