High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester

Jung Min Lee, Mo Beom Koo, Seul Woo Lee, Heelim Lee, Junho Kwon, Yul Hui Shim, So Youn Kim and Kyoung Taek Kim ()
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Jung Min Lee: Seoul National University
Mo Beom Koo: Seoul National University
Seul Woo Lee: Seoul National University
Heelim Lee: Seoul National University
Junho Kwon: Seoul National University
Yul Hui Shim: Ulsan National Institute of Science and Technology (UNIST)
So Youn Kim: Ulsan National Institute of Science and Technology (UNIST)
Kyoung Taek Kim: Seoul National University

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Synthesis of a polymer composed of a large discrete number of chemically distinct monomers in an absolutely defined aperiodic sequence remains a challenge in polymer chemistry. The synthesis has largely been limited to oligomers having a limited number of repeating units due to the difficulties associated with the step-by-step addition of individual monomers to achieve high molecular weights. Here we report the copolymers of α-hydroxy acids, poly(phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method from four dyads of monomers as constituent units. Our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information can be stored in an aperiodic sequence of PcL, which can be fully retrieved as binary code by mass spectrometry sequencing. The information storage density (bit/Da) of PcL is 50% higher than DNA, and the storage capacity of PcL can also be increased by adjusting the molecular weight (~38 kDa).

Date: 2020
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DOI: 10.1038/s41467-019-13952-2

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