Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

Kerri G. Lal, Dohoon Kim, Margaret C. Costanzo, Matthew Creegan, Edwin Leeansyah, Joana Dias, Dominic Paquin-Proulx, Leigh Anne Eller, Alexandra Schuetz, Yuwadee Phuang-ngern, Shelly J. Krebs, Bonnie M. Slike, Hannah Kibuuka, Lucas Maganga, Sorachai Nitayaphan, Josphat Kosgei, Carlo Sacdalan, Jintanat Ananworanich, Diane L. Bolton, Nelson L. Michael, Barbara L. Shacklett, Merlin L. Robb, Michael A. Eller and Johan K. Sandberg ()
Additional contact information
Kerri G. Lal: Walter Reed Army Institute of Research
Dohoon Kim: Walter Reed Army Institute of Research
Margaret C. Costanzo: Walter Reed Army Institute of Research
Matthew Creegan: Walter Reed Army Institute of Research
Edwin Leeansyah: Karolinska Institutet
Joana Dias: Karolinska Institutet
Dominic Paquin-Proulx: Walter Reed Army Institute of Research
Leigh Anne Eller: Walter Reed Army Institute of Research
Alexandra Schuetz: Walter Reed Army Institute of Research
Yuwadee Phuang-ngern: Armed Forces Research Institute of Medical Sciences
Shelly J. Krebs: Walter Reed Army Institute of Research
Bonnie M. Slike: Walter Reed Army Institute of Research
Hannah Kibuuka: Makerere University Walter Reed Project
Lucas Maganga: National Institute for Medical Research-Mbeya Medical Research Center
Sorachai Nitayaphan: Armed Forces Research Institute of Medical Sciences
Josphat Kosgei: Kenya Medical Research Institute/U.S. Army Medical Research Directorate-Africa/Kenya
Carlo Sacdalan: SEARCH, The Thai Red Cross AIDS Research Centre
Jintanat Ananworanich: Walter Reed Army Institute of Research
Diane L. Bolton: Walter Reed Army Institute of Research
Nelson L. Michael: Walter Reed Army Institute of Research
Barbara L. Shacklett: University of California Davis
Merlin L. Robb: Walter Reed Army Institute of Research
Michael A. Eller: Walter Reed Army Institute of Research
Johan K. Sandberg: Karolinska Institutet

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-13975-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13975-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-13975-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().