Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Murugan Subbiah, Mark A. Caudell (), Colette Mair, Margaret A. Davis, Louise Matthews, Robert J. Quinlan, Marsha B. Quinlan, Beatus Lyimo, Joram Buza, Julius Keyyu and Douglas R. Call
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Murugan Subbiah: Washington State University
Mark A. Caudell: Washington State University
Colette Mair: University of Glasgow
Margaret A. Davis: Washington State University
Louise Matthews: University of Glasgow
Robert J. Quinlan: Washington State University
Marsha B. Quinlan: Washington State University
Beatus Lyimo: Nelson Mandela African Institution of Science and Technology
Joram Buza: Nelson Mandela African Institution of Science and Technology
Julius Keyyu: Tanzania Wildlife Research Institute
Douglas R. Call: Washington State University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.

Date: 2020
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DOI: 10.1038/s41467-019-13995-5

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