An electrochemical biosensor for the detection of epithelial-mesenchymal transition

Xin Du, Zhenhua Zhang, Xiaodi Zheng, Hongyan Zhang, Dan Dong, Zhenguo Zhang, Min Liu () and Jun Zhou ()
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Xin Du: Shandong Normal University
Zhenhua Zhang: Shandong Normal University
Xiaodi Zheng: Shandong Normal University
Hongyan Zhang: Shandong Normal University
Dan Dong: Shandong Normal University
Zhenguo Zhang: Shandong Normal University
Min Liu: Shandong Normal University
Jun Zhou: Shandong Normal University

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Epithelial-mesenchymal transition (EMT) is critically involved in a variety of biological processes. Electrochemical sensing offers potential to develop more effective technology for EMT detection. In this study, by using the unique performance of quantum dot (QD)-nanocomposite materials, we establish an electrochemical biosensor that can specifically detect the change of E-cadherin and analyze different stages of EMT. The signal for EMT is largely magnified due to the transmission of molecular information to the electronic device. In addition, differential pulse voltammetry reveals that the response of the electrochemical signals is rapid and sensitive, due to the synergistic effect of QDs and carbon nanotube-gold nanoparticles. Our study thus suggests that electrochemical sensing is an effective technology for detecting EMT and may have broad applications in analyzing various cell type transitions.

Date: 2020
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DOI: 10.1038/s41467-019-14037-w

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