A comparative genomics study of 23 Aspergillus species from section Flavi

Inge Kjærbølling, Tammi Vesth, Jens C. Frisvad, Jane L. Nybo, Sebastian Theobald, Sara Kildgaard, Thomas Isbrandt Petersen, Alan Kuo, Atsushi Sato, Ellen K. Lyhne, Martin E. Kogle, Ad Wiebenga, Roland S. Kun, Ronnie J. M. Lubbers, Miia R. Mäkelä, Kerrie Barry, Mansi Chovatia, Alicia Clum, Chris Daum, Sajeet Haridas, Guifen He, Kurt LaButti, Anna Lipzen, Stephen Mondo, Jasmyn Pangilinan, Robert Riley, Asaf Salamov, Blake A. Simmons, Jon K. Magnuson, Bernard Henrissat, Uffe H. Mortensen, Thomas O. Larsen, Ronald P. Vries, Igor V. Grigoriev, Masayuki Machida, Scott E. Baker and Mikael R. Andersen ()
Additional contact information
Inge Kjærbølling: Technical University of Denmark
Tammi Vesth: Technical University of Denmark
Jens C. Frisvad: Technical University of Denmark
Jane L. Nybo: Technical University of Denmark
Sebastian Theobald: Technical University of Denmark
Sara Kildgaard: Technical University of Denmark
Thomas Isbrandt Petersen: Technical University of Denmark
Alan Kuo: US Department of Energy Joint Genome Institute
Atsushi Sato: Kikkoman Corporation
Ellen K. Lyhne: Technical University of Denmark
Martin E. Kogle: Technical University of Denmark
Ad Wiebenga: Utrecht University
Roland S. Kun: Utrecht University
Ronnie J. M. Lubbers: Utrecht University
Miia R. Mäkelä: University of Helsinki
Kerrie Barry: US Department of Energy Joint Genome Institute
Mansi Chovatia: US Department of Energy Joint Genome Institute
Alicia Clum: US Department of Energy Joint Genome Institute
Chris Daum: US Department of Energy Joint Genome Institute
Sajeet Haridas: US Department of Energy Joint Genome Institute
Guifen He: US Department of Energy Joint Genome Institute
Kurt LaButti: US Department of Energy Joint Genome Institute
Anna Lipzen: US Department of Energy Joint Genome Institute
Stephen Mondo: US Department of Energy Joint Genome Institute
Jasmyn Pangilinan: US Department of Energy Joint Genome Institute
Robert Riley: US Department of Energy Joint Genome Institute
Asaf Salamov: US Department of Energy Joint Genome Institute
Blake A. Simmons: US Department of Energy Joint BioEnergy Institute
Jon K. Magnuson: US Department of Energy Joint BioEnergy Institute
Bernard Henrissat: Aix-Marseille University
Uffe H. Mortensen: Technical University of Denmark
Thomas O. Larsen: Technical University of Denmark
Ronald P. Vries: Utrecht University
Igor V. Grigoriev: US Department of Energy Joint Genome Institute
Masayuki Machida: Kanazawa Institute of Technology
Scott E. Baker: US Department of Energy Joint BioEnergy Institute
Mikael R. Andersen: Technical University of Denmark

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Section Flavi encompasses both harmful and beneficial Aspergillus species, such as Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food spoiler and mycotoxin producer. Here, we sequence 19 genomes spanning section Flavi and compare 31 fungal genomes including 23 Flavi species. We reassess their phylogenetic relationships and show that the closest relative of A. oryzae is not A. flavus, but A. minisclerotigenes or A. aflatoxiformans and identify high genome diversity, especially in sub-telomeric regions. We predict abundant CAZymes (598 per species) and prolific secondary metabolite gene clusters (73 per species) in section Flavi. However, the observed phenotypes (growth characteristics, polysaccharide degradation) do not necessarily correlate with inferences made from the predicted CAZyme content. Our work, including genomic analyses, phenotypic assays, and identification of secondary metabolites, highlights the genetic and metabolic diversity within section Flavi.

Date: 2020
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DOI: 10.1038/s41467-019-14051-y

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