Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

Yang Li, Mingyou Zhang, Xiaodan Wang, Wentao Liu, Hui Wang and Yong-Guang Yang ()
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Yang Li: Jilin University
Mingyou Zhang: Jilin University
Xiaodan Wang: Jilin University
Wentao Liu: Jilin University
Hui Wang: Columbia University Medical Center
Yong-Guang Yang: Jilin University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Cancer cells are poorly immunogenic and have a wide range of mutations, which makes them unsuitable for use in vaccination treatment. Here, we show that elimination of CD47, a ligand for the myeloid cell inhibitory receptor SIRPα, from tumor cells by genetic deletion or antibody blocking, significantly improves the effectiveness of the immune response to tumour cells. In both solid and hematopoietic mouse tumor models, vaccination with tumor cells or tumor antigen-expressing cells, that lack CD47 or were pre-coated with anti-CD47 antibodies, achieved an antitumor immune response. The efficacy of this approach was synergistically enhanced when used in combination with anti-PD-1 antibodies. The induction of antitumor responses depends on SIRPα+CD11c+ DCs, which exhibit rapid expansion following introduction of CD47-deficient tumor cells. Our results indicate that CD47-deficient whole tumor cells can induce antitumor responses.

Date: 2020
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DOI: 10.1038/s41467-019-14102-4

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