Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent

Xin Zeng, Jie Sun, Suping Li, Jiyun Shi, Han Gao, Wei Sun Leong, Yiqi Wu, Minghui Li, Chengxin Liu, Ping Li, Jing Kong, Yi-Zhou Wu (), Guangjun Nie (), Yuming Fu () and Gen Zhang ()
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Xin Zeng: Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital
Jie Sun: Nanjing Medical University
Suping Li: CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China
Jiyun Shi: Chinese Academy of Sciences
Han Gao: Beihang University
Wei Sun Leong: Massachusetts Institute of Technology
Yiqi Wu: Nanjing Medical University
Minghui Li: Nanjing Medical University
Chengxin Liu: Nanjing Medical University
Ping Li: Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital
Jing Kong: Massachusetts Institute of Technology
Yi-Zhou Wu: Nanjing Medical University
Guangjun Nie: CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China
Yuming Fu: Beihang University
Gen Zhang: Nanjing Medical University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Since the discovery of metal nanoparticles (NPs) in the 1960s, unknown toxicity, cost and the ethical hurdles of research in humans have hindered the translation of these NPs to clinical use. In this work, we demonstrate that Pt NPs with protein coronas are generated in vivo in human blood when a patient is treated with cisplatin. These self-assembled Pt NPs form rapidly, accumulate in tumors, and remain in the body for an extended period of time. Additionally, the Pt NPs are safe for use in humans and can act as anti-cancer agents to inhibit chemotherapy-resistant tumor growth by consuming intracellular glutathione and activating apoptosis. The tumor inhibitory activity is greatly amplified when the Pt NPs are loaded in vitro with the chemotherapeutic drug, daunorubicin, and the formulation is effective even in daunorubicin-resistant models. These in vivo-generated metal NPs represent a biocompatible drug delivery platform for chemotherapy resistant tumor treatment.

Date: 2020
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DOI: 10.1038/s41467-019-14131-z

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