Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Dongdong Wang, Huihui Wu, Soo Zeng Fiona Phua, Guangbao Yang, Wei Qi Lim, Long Gu, Cheng Qian, Haibao Wang, Zhen Guo (), Hongzhong Chen and Yanli Zhao ()
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Dongdong Wang: Nanyang Technological University
Huihui Wu: University of Science and Technology of China
Soo Zeng Fiona Phua: Nanyang Technological University
Guangbao Yang: Nanyang Technological University
Wei Qi Lim: Nanyang Technological University
Long Gu: Nanyang Technological University
Cheng Qian: Nanyang Technological University
Haibao Wang: Radiology Department of the First Affiliated Hospital of Anhui Medical University
Zhen Guo: University of Science and Technology of China
Hongzhong Chen: Nanyang Technological University
Yanli Zhao: Nanyang Technological University

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The resulted OxgeMCC-r SAE possesses well-defined morphology, uniform size distribution and high loading capacity. When conducting the in situ O2 generation through the reaction between endogenous H2O2 and single-atom Ru species of OxgeMCC-r SAE, the hypoxia in tumor microenvironment is relieved. Our study demonstrates a promising self-assembled nanozyme with highly efficient single-atom catalytic sites for cancer treatment.

Date: 2020
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DOI: 10.1038/s41467-019-14199-7

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