Maternal paraben exposure triggers childhood overweight development

Beate Leppert, Sandra Strunz, Bettina Seiwert, Linda Schlittenbauer, Rita Schlichting, Christiane Pfeiffer, Stefan Röder, Mario Bauer, Michael Borte, Gabriele I. Stangl, Torsten Schöneberg, Angela Schulz, Isabell Karkossa, Ulrike E. Rolle-Kampczyk, Loreen Thürmann, Martin von Bergen, Beate I. Escher, Kristin M. Junge, Thorsten Reemtsma, Irina Lehmann () and Tobias Polte ()
Additional contact information
Beate Leppert: Helmholtz Centre for Environmental Research—UFZ
Sandra Strunz: Helmholtz Centre for Environmental Research—UFZ
Bettina Seiwert: Helmholtz Centre for Environmental Research—UFZ
Linda Schlittenbauer: Helmholtz Centre for Environmental Research—UFZ
Rita Schlichting: Helmholtz Centre for Environmental Research—UFZ
Christiane Pfeiffer: Helmholtz Centre for Environmental Research—UFZ
Stefan Röder: Helmholtz Centre for Environmental Research—UFZ
Mario Bauer: Helmholtz Centre for Environmental Research—UFZ
Michael Borte: Children’s Hospital, Municipal Hospital St. Georg
Gabriele I. Stangl: Martin Luther University Halle-Wittenberg
Torsten Schöneberg: University of Leipzig
Angela Schulz: University of Leipzig
Isabell Karkossa: Helmholtz Centre for Environmental Research—UFZ
Ulrike E. Rolle-Kampczyk: Helmholtz Centre for Environmental Research—UFZ
Loreen Thürmann: Helmholtz Centre for Environmental Research—UFZ
Martin von Bergen: Helmholtz Centre for Environmental Research—UFZ
Beate I. Escher: Helmholtz Centre for Environmental Research—UFZ
Kristin M. Junge: Helmholtz Centre for Environmental Research—UFZ
Thorsten Reemtsma: Helmholtz Centre for Environmental Research—UFZ
Irina Lehmann: Helmholtz Centre for Environmental Research—UFZ
Tobias Polte: Helmholtz Centre for Environmental Research—UFZ

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially in recent years. Here we investigate the effect of prenatal paraben exposure on childhood overweight by combining epidemiological data from a mother–child cohort with experimental approaches. Mothers reporting the use of paraben-containing cosmetic products have elevated urinary paraben concentrations. For butyl paraben (BuP) a positive association is observed to overweight within the first eight years of life with a stronger trend in girls. Consistently, maternal BuP exposure of mice induces a higher food intake and weight gain in female offspring. The effect is accompanied by an epigenetic modification in the neuronal Pro-opiomelanocortin (POMC) enhancer 1 leading to a reduced hypothalamic POMC expression. Here we report that maternal paraben exposure may contribute to childhood overweight development by altered POMC-mediated neuronal appetite regulation.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14202-1

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DOI: 10.1038/s41467-019-14202-1

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