Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate

Xue Wang, Haibo Xu, Chaping Cheng, Zhongzhong Ji, Huifang Zhao, Yaru Sheng, Xiaoxia Li, Jinming Wang, Yu Shu, Yuman He, Liancheng Fan, Baijun Dong, Wei Xue, Chee Wai Chua, Dongdong Wu, Wei-Qiang Gao () and Helen He Zhu ()
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Xue Wang: Shanghai Jiao Tong University
Haibo Xu: Kunming Institute of Sciences
Chaping Cheng: Shanghai Jiao Tong University
Zhongzhong Ji: Shanghai Jiao Tong University
Huifang Zhao: Shanghai Jiao Tong University
Yaru Sheng: Shanghai Jiao Tong University
Xiaoxia Li: Shanghai Jiao Tong University
Jinming Wang: Shanghai Jiao Tong University
Yu Shu: Shanghai Jiao Tong University
Yuman He: Shanghai Jiao Tong University
Liancheng Fan: Shanghai Jiao Tong University
Baijun Dong: Shanghai Jiao Tong University
Wei Xue: Shanghai Jiao Tong University
Chee Wai Chua: Shanghai Jiao Tong University
Dongdong Wu: Kunming Institute of Sciences
Wei-Qiang Gao: Shanghai Jiao Tong University
Helen He Zhu: Shanghai Jiao Tong University

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells. However, basal cells are heterogenous and the stem cell subpopulation within basal cells is not well elucidated. Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation. The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level. Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development. Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset. Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. Identification of the PBSC and its transcriptome profile is crucial to advance our understanding of prostate development and tumorigenesis.

Date: 2020
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DOI: 10.1038/s41467-020-14296-y

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