H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

Luyan Wu, Yusuke Ishigaki, Yuxuan Hu, Keisuke Sugimoto, Wenhui Zeng, Takashi Harimoto, Yidan Sun, Jian He, Takanori Suzuki (), Xiqun Jiang, Hong-Yuan Chen and Deju Ye ()
Additional contact information
Luyan Wu: Nanjing University
Yusuke Ishigaki: Hokkaido University
Yuxuan Hu: Nanjing University
Keisuke Sugimoto: Hokkaido University
Wenhui Zeng: Nanjing University
Takashi Harimoto: Hokkaido University
Yidan Sun: Nanjing University
Jian He: The Affiliated Hospital of Nanjing University Medical School
Takanori Suzuki: Hokkaido University
Xiqun Jiang: Nanjing University
Hong-Yuan Chen: Nanjing University
Deju Ye: Nanjing University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo imaging; however, such probes that can be selectively delivered into target sites and switch on afterglow luminescence remain limited. We optimize an organic electrochromic material and integrate it into near-infrared (NIR) photosensitizer (silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) and (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) containing nanoparticles, developing an H2S-activatable NIR afterglow probe (F12+-ANP). F12+-ANP displays a fast reaction rate (1563 ± 141 M−1 s−1) and large afterglow turn-on ratio (~122-fold) toward H2S, enabling high-sensitivity and -specificity measurement of H2S concentration in bloods from healthy persons, hepatic or colorectal cancer patients. We further construct a hepatic-tumor-targeting and H2S-activatable afterglow probe (F12+-ANP-Gal) for noninvasive, real-time imaging of tiny subcutaneous HepG2 tumors (

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (8)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-14307-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14307-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-14307-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().