Organizing genome engineering for the gigabase scale

Bryan A. Bartley, Jacob Beal (), Jonathan R. Karr and Elizabeth A. Strychalski
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Bryan A. Bartley: Raytheon BBN Technologies
Jacob Beal: Raytheon BBN Technologies
Jonathan R. Karr: Icahn School of Medicine at Mount Sinai
Elizabeth A. Strychalski: National Institute of Standards and Technology

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Genome-scale engineering holds great potential to impact science, industry, medicine, and society, and recent improvements in DNA synthesis have enabled the manipulation of megabase genomes. However, coordinating and integrating the workflows and large teams necessary for gigabase genome engineering remains a considerable challenge. We examine this issue and recommend a path forward by: 1) adopting and extending existing representations for designs, assembly plans, samples, data, and workflows; 2) developing new technologies for data curation and quality control; 3) conducting fundamental research on genome-scale modeling and design; and 4) developing new legal and contractual infrastructure to facilitate collaboration.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14314-z

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DOI: 10.1038/s41467-020-14314-z

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