Decorating bacteria with self-assembled synthetic receptors

Naama Lahav-Mankovski, Pragati Kishore Prasad, Noa Oppenheimer-Low, Gal Raviv, Tali Dadosh, Tamar Unger, Tomer Meir Salame, Leila Motiei () and David Margulies ()
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Naama Lahav-Mankovski: Weizmann Institute of Science
Pragati Kishore Prasad: Weizmann Institute of Science
Noa Oppenheimer-Low: Weizmann Institute of Science
Gal Raviv: Weizmann Institute of Science
Tali Dadosh: Weizmann Institute of Science
Tamar Unger: Weizmann Institute of Science
Tomer Meir Salame: Weizmann Institute of Science
Leila Motiei: Weizmann Institute of Science
David Margulies: Weizmann Institute of Science

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract The responses of cells to their surroundings are mediated by the binding of cell surface proteins (CSPs) to extracellular signals. Such processes are regulated via dynamic changes in the structure, composition, and expression levels of CSPs. In this study, we demonstrate the possibility of decorating bacteria with artificial, self-assembled receptors that imitate the dynamic features of CSPs. We show that the local concentration of these receptors on the bacterial membrane and their structure can be reversibly controlled using suitable chemical signals, in a way that resembles changes that occur with CSP expression levels or posttranslational modifications (PTMs), respectively. We also show that these modifications can endow the bacteria with programmable properties, akin to the way CSP responses can induce cellular functions. By programming the bacteria to glow, adhere to surfaces, or interact with proteins or mammalian cells, we demonstrate the potential to tailor such biomimetic systems for specific applications.

Date: 2020
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DOI: 10.1038/s41467-020-14336-7

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