A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease

Qingcai Liu, Suining Deng, Baoshen Liu, Yongfu Tao, Haiyue Ai, Jianju Liu, Yongzhong Zhang, Yan Zhao and Mingliang Xu ()
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Qingcai Liu: China Agricultural University
Suining Deng: China Agricultural University
Baoshen Liu: Shandong Agricultural University
Yongfu Tao: China Agricultural University
Haiyue Ai: China Agricultural University
Jianju Liu: China Agricultural University
Yongzhong Zhang: Shandong Agricultural University
Yan Zhao: Shandong Agricultural University
Mingliang Xu: China Agricultural University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibitor alpha (RabGDIα) is the host susceptibility factor for RBSDV. The viral P7-1 protein binds tightly to the exon-10 and C-terminal regions of RabGDIα to recruit it for viral infection. Insertion of a helitron transposon into RabGDIα intron 10 creates alternative splicing to replace the wild-type exon 10 with a helitron-derived exon 10. The resultant splicing variant RabGDIα-hel has difficulty being recruited by P7-1, thus leading to quantitative recessive resistance to MRDD. All naturally occurring resistance alleles may have arisen from a recent single helitron insertion event. These resistance alleles are valuable to improve maize resistance to MRDD and potentially to engineer RBSDV resistance in other crops.

Date: 2020
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DOI: 10.1038/s41467-020-14372-3

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