Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Agian Jeffilano Barinda, Koji Ikeda (), Dhite Bayu Nugroho, Donytra Arby Wardhana, Naoto Sasaki, Sakiko Honda, Ryota Urata, Satoaki Matoba, Ken-ichi Hirata and Noriaki Emoto
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Agian Jeffilano Barinda: Kobe Pharmaceutical University
Koji Ikeda: Kobe Pharmaceutical University
Dhite Bayu Nugroho: Kobe Pharmaceutical University
Donytra Arby Wardhana: Kobe Pharmaceutical University
Naoto Sasaki: Kobe Pharmaceutical University
Sakiko Honda: Kyoto Prefectural University Graduate School of Medical Science
Ryota Urata: Kyoto Prefectural University Graduate School of Medical Science
Satoaki Matoba: Kyoto Prefectural University Graduate School of Medical Science
Ken-ichi Hirata: Kobe University Graduate School of Medicine
Noriaki Emoto: Kobe Pharmaceutical University

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that endothelial cell (EC) senescence induces metabolic disorders through the senescence-associated secretory phenotype. Senescence-messaging secretomes from senescent ECs induced a senescence-like state and reduced insulin receptor substrate-1 in adipocytes, which thereby impaired insulin signaling. We generated EC-specific progeroid mice that overexpressed the dominant negative form of telomeric repeat-binding factor 2 under the control of the Tie2 promoter. EC-specific progeria impaired systemic metabolic health in mice in association with adipose tissue dysfunction even while consuming normal chow. Notably, shared circulation with EC-specific progeroid mice by parabiosis sufficiently transmitted the metabolic disorders into wild-type recipient mice. Our data provides direct evidence that EC senescence impairs systemic metabolic health, and thus establishes EC senescence as a bona fide risk for age-related metabolic disease.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14387-w

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DOI: 10.1038/s41467-020-14387-w

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