Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nikos Papadimitriou, Niki Dimou, Konstantinos K. Tsilidis, Barbara Banbury, Richard M. Martin, Sarah J. Lewis, Nabila Kazmi, Timothy M. Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I. Berndt, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Bas Bueno- de-Mesquita, Peter T. Campbell, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Merete Ellingjord-Dale, Jane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Edward Giovannucci, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Li Hsu, José María Huerta, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Tilman Kühn, Carlo Vecchia, Loic Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Brigid Lynch, Sanford D. Markowitz, Giovanna Masala, Anne M. May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Vittorio Perduca, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Elio Riboli, Maria-Jose Sánchez, Stephanie L. Schmit, Robert E. Schoen, Gianluca Severi, Sabina Sieri, Martha L. Slattery, Mingyang Song, Catherine M. Tangen, Stephen N. Thibodeau, Ruth C. Travis, Antonia Trichopoulou, Cornelia M. Ulrich, Franzel J. B. Duijnhoven, Bethany Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Marc J. Gunter and Neil Murphy ()
Additional contact information
Nikos Papadimitriou: International Agency for Research on Cancer
Niki Dimou: International Agency for Research on Cancer
Konstantinos K. Tsilidis: University of Ioannina School of Medicine
Barbara Banbury: Fred Hutchinson Cancer Research Center
Richard M. Martin: Bristol Medical School, University of Bristol
Sarah J. Lewis: University of Bristol
Nabila Kazmi: Bristol Medical School, University of Bristol
Timothy M. Robinson: University of Bristol
Demetrius Albanes: National Institutes of Health
Krasimira Aleksandrova: Arthur-Scheunert-Allee 114-116
Sonja I. Berndt: National Institutes of Health
D. Timothy Bishop: University of Leeds
Hermann Brenner: German Cancer Research Center (DKFZ)
Daniel D. Buchanan: The University of Melbourne
Bas Bueno- de-Mesquita: National Institute for Public Health and the Environment (RIVM), PO Box 1
Peter T. Campbell: American Cancer Society
Sergi Castellví-Bel: University of Barcelona
Andrew T. Chan: Massachusetts General Hospital and Harvard Medical School
Jenny Chang-Claude: German Cancer Research Center (DKFZ)
Merete Ellingjord-Dale: Imperial College London
Jane C. Figueiredo: Cedars-Sinai Medical Center
Steven J. Gallinger: University of Toronto
Graham G. Giles: The University of Melbourne
Edward Giovannucci: Harvard University
Stephen B. Gruber: University of Southern California
Andrea Gsur: Medical University Vienna
Jochen Hampe: University Hospital Dresden, Technische Universität Dresden (TU Dresden)
Heather Hampel: The Ohio State University Comprehensive Cancer Center
Sophia Harlid: Oncology, Umea University
Tabitha A. Harrison: Fred Hutchinson Cancer Research Center
Michael Hoffmeister: German Cancer Research Center (DKFZ)
John L. Hopper: The University of Melbourne
Li Hsu: Fred Hutchinson Cancer Research Center
José María Huerta: CIBER de Epidemiología y Salud Pública (CIBERESP)
Jeroen R. Huyghe: Fred Hutchinson Cancer Research Center
Mark A. Jenkins: The University of Melbourne
Temitope O. Keku: University of North Carolina
Tilman Kühn: German Cancer Research Center (DKFZ)
Carlo Vecchia: Hellenic Health Foundation
Loic Marchand: University of Hawaii Cancer Center
Christopher I. Li: Fred Hutchinson Cancer Research Center
Li Li: University of Virginia
Annika Lindblom: Karolinska University Hospital
Noralane M. Lindor: Mayo Clinic
Brigid Lynch: The University of Melbourne
Sanford D. Markowitz: Case Western Reserve University, and University Hospitals of Cleveland
Giovanna Masala: Institute for Cancer Research, Prevention and Clinical Network - ISPRO
Anne M. May: University Medical Center Utrecht, Utrecht University, P.O. Box 85500
Roger Milne: The University of Melbourne
Evelyn Monninkhof: University Medical Center Utrecht, Utrecht University, P.O. Box 85500
Lorena Moreno: University of Barcelona
Victor Moreno: CIBER de Epidemiología y Salud Pública (CIBERESP)
Polly A. Newcomb: Fred Hutchinson Cancer Research Center
Kenneth Offit: Memorial Sloan-Kettering Cancer Center
Vittorio Perduca: CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay
Paul D. P. Pharoah: University of Cambridge
Elizabeth A. Platz: Johns Hopkins Bloomberg School of Public Health
John D. Potter: Fred Hutchinson Cancer Research Center
Gad Rennert: Lady Davis Carmel Medical Center
Elio Riboli: Imperial College London
Maria-Jose Sánchez: CIBER de Epidemiología y Salud Pública (CIBERESP)
Stephanie L. Schmit: University of Southern California
Robert E. Schoen: University of Pittsburgh Medical Center
Gianluca Severi: CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay
Sabina Sieri: Fondazione IRCCS Istituto Nazionale dei Tumori
Martha L. Slattery: University of Utah
Mingyang Song: Massachusetts General Hospital and Harvard Medical School
Catherine M. Tangen: Fred Hutchinson Cancer Research Center
Stephen N. Thibodeau: Mayo Clinic
Ruth C. Travis: University of Oxford
Antonia Trichopoulou: Hellenic Health Foundation
Cornelia M. Ulrich: University of Utah
Franzel J. B. Duijnhoven: Wageningen University and Research
Bethany Guelpen: Umeå University
Pavel Vodicka: Institute of Experimental Medicine of the Czech Academy of Sciences
Emily White: Fred Hutchinson Cancer Research Center
Alicja Wolk: Karolinska Institutet
Michael O. Woods: Discipline of Genetics
Anna H. Wu: University of Southern California, Preventative Medicine
Ulrike Peters: Fred Hutchinson Cancer Research Center
Marc J. Gunter: International Agency for Research on Cancer
Neil Murphy: International Agency for Research on Cancer

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

Date: 2020
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DOI: 10.1038/s41467-020-14389-8

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