Surface protein imputation from single cell transcriptomes by deep neural networks

Zilu Zhou, Chengzhong Ye, Jingshu Wang and Nancy R. Zhang ()
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Zilu Zhou: University of Pennsylvania
Chengzhong Ye: Tsinghua University
Jingshu Wang: The University of Chicago
Nancy R. Zhang: University of Pennsylvania

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract While single cell RNA sequencing (scRNA-seq) is invaluable for studying cell populations, cell-surface proteins are often integral markers of cellular function and serve as primary targets for therapeutic intervention. Here we propose a transfer learning framework, single cell Transcriptome to Protein prediction with deep neural network (cTP-net), to impute surface protein abundances from scRNA-seq data by learning from existing single-cell multi-omic resources.

Date: 2020
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DOI: 10.1038/s41467-020-14391-0

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