Microchannel network hydrogel induced ischemic blood perfusion connection

Jung Bok Lee, Dae-Hyun Kim, Jeong-Kee Yoon, Dan Bi Park, Hye-Seon Kim, Young Min Shin, Wooyeol Baek, Mi-Lan Kang, Hyun Jung Kim and Hak-Joon Sung ()
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Jung Bok Lee: Yonsei University College of Medicine
Dae-Hyun Kim: Yonsei University College of Medicine
Jeong-Kee Yoon: Yonsei University College of Medicine
Dan Bi Park: Yonsei University College of Medicine
Hye-Seon Kim: Yonsei University College of Medicine
Young Min Shin: Yonsei University College of Medicine
Wooyeol Baek: Yonsei University College of Medicine
Mi-Lan Kang: Yonsei University College of Medicine
Hyun Jung Kim: Yonsei University College of Medicine
Hak-Joon Sung: Yonsei University College of Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Angiogenesis induction into damaged sites has long been an unresolved issue. Local treatment with pro-angiogenic molecules has been the most common approach. However, this approach has critical side effects including inflammatory coupling, tumorous vascular activation, and off-target circulation. Here, the concept that a structure can guide desirable biological function is applied to physically engineer three-dimensional channel networks in implant sites, without any therapeutic treatment. Microchannel networks are generated in a gelatin hydrogel to overcome the diffusion limit of nutrients and oxygen three-dimensionally. Hydrogel implantation in mouse and porcine models of hindlimb ischemia rescues severely damaged tissues by the ingrowth of neighboring host vessels with microchannel perfusion. This effect is guided by microchannel size-specific regenerative macrophage polarization with the consequent functional recovery of endothelial cells. Multiple-site implantation reveals hypoxia and neighboring vessels as major causative factors of the beneficial function. This technique may contribute to the development of therapeutics for hypoxia/inflammatory-related diseases.

Date: 2020
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DOI: 10.1038/s41467-020-14480-0

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