Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

Lucy K. Bicks, Kazuhiko Yamamuro, Meghan E. Flanigan, Julia Minjung Kim, Daisuke Kato, Elizabeth K. Lucas, Hiroyuki Koike, Michelle S. Peng, Daniel M. Brady, Sandhya Chandrasekaran, Kevin J. Norman, Milo R. Smith, Roger L. Clem, Scott J. Russo, Schahram Akbarian and Hirofumi Morishita ()
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Lucy K. Bicks: Icahn School of Medicine at Mount Sinai
Kazuhiko Yamamuro: Icahn School of Medicine at Mount Sinai
Meghan E. Flanigan: Icahn School of Medicine at Mount Sinai
Julia Minjung Kim: Icahn School of Medicine at Mount Sinai
Daisuke Kato: Icahn School of Medicine at Mount Sinai
Elizabeth K. Lucas: Icahn School of Medicine at Mount Sinai
Hiroyuki Koike: Icahn School of Medicine at Mount Sinai
Michelle S. Peng: Icahn School of Medicine at Mount Sinai
Daniel M. Brady: Icahn School of Medicine at Mount Sinai
Sandhya Chandrasekaran: Icahn School of Medicine at Mount Sinai
Kevin J. Norman: Icahn School of Medicine at Mount Sinai
Milo R. Smith: Icahn School of Medicine at Mount Sinai
Roger L. Clem: Icahn School of Medicine at Mount Sinai
Scott J. Russo: Icahn School of Medicine at Mount Sinai
Schahram Akbarian: Icahn School of Medicine at Mount Sinai
Hirofumi Morishita: Icahn School of Medicine at Mount Sinai

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Social isolation during the juvenile critical window is detrimental to proper functioning of the prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, the specific circuits that undergo social experience-dependent maturation to regulate social behavior are poorly understood. We identify a specific activation pattern of parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior to an active bout, or a bout initiated by the focal mouse, but not during a passive bout when mice are explored by a stimulus mouse. Optogenetic and chemogenetic manipulation reveals that brief dmPFC-PVI activation triggers an active social approach to promote sociability. Juvenile social isolation decouples dmPFC-PVI activation from subsequent active social approach by freezing the functional maturation process of dmPFC-PVIs during the juvenile-to-adult transition. Chemogenetic activation of dmPFC-PVI activity in the adult animal mitigates juvenile isolation-induced social deficits. Therefore, social experience-dependent maturation of dmPFC-PVI is linked to long-term impacts on social behavior.

Date: 2020
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DOI: 10.1038/s41467-020-14740-z

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