Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila

Stéphanie Soulé, Lucille Mellottée, Abdelkrim Arab, Chongjian Chen and Jean-René Martin ()
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Stéphanie Soulé: CNRS/Université Paris Sud
Lucille Mellottée: CNRS/Université Paris Sud
Abdelkrim Arab: CNRS/Université Paris Sud
Chongjian Chen: Mammalian Developmental Epigenetics Group (E. Heard Lab.), Institut Curie, CNRS UMR-3215
Jean-René Martin: CNRS/Université Paris Sud

Nature Communications, 2020, vol. 11, issue 1, 1-21

Abstract: Abstract Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its overexpression in wild-type increases lifespan. Jouvence is required in enterocytes. In mutant, the epithelium of the gut presents more hyperplasia, while the overexpression of jouvence prevents it. Molecularly, the mutant lack pseudouridylation on 18S and 28S-rRNA, a function rescued by targeted expression of jouvence in the gut. A transcriptomic analysis performed from the gut reveals that several genes are either up- or down-regulated, while restoring the mRNA level of two genes (ninaD or CG6296) rescue the longevity. Since snoRNAs are structurally and functionally well conserved throughout evolution, we identified putative jouvence orthologue in mammals including humans, suggesting that its function in longevity could be conserved.

Date: 2020
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DOI: 10.1038/s41467-020-14784-1

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