Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling

Hongying Fu, Hengda Zhou, Xinghai Yu, Jingxiu Xu, Jinghua Zhou, Xinan Meng, Jianzhi Zhao, Yu Zhou, Andrew D. Chisholm and Suhong Xu ()
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Hongying Fu: Zhejiang University School of Medicine
Hengda Zhou: Zhejiang University School of Medicine
Xinghai Yu: Wuhan University
Jingxiu Xu: Zhejiang University School of Medicine
Jinghua Zhou: Zhejiang University School of Medicine
Xinan Meng: Zhejiang University School of Medicine
Jianzhi Zhao: Zhejiang University School of Medicine
Yu Zhou: Wuhan University
Andrew D. Chisholm: University of California
Suhong Xu: Zhejiang University School of Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Organisms respond to tissue damage through the upregulation of protective responses which restore tissue structure and metabolic function. Mitochondria are key sources of intracellular oxidative metabolic signals that maintain cellular homeostasis. Here we report that tissue and cellular wounding triggers rapid and reversible mitochondrial fragmentation. Elevated mitochondrial fragmentation either in fzo-1 fusion-defective mutants or after acute drug treatment accelerates actin-based wound closure. Wounding triggered mitochondrial fragmentation is independent of the GTPase DRP-1 but acts via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca2+. The fragmented mitochondria and accelerated wound closure of fzo-1 mutants are dependent on MIRO-1 function. Genetic and transcriptomic analyzes show that enhanced mitochondrial fragmentation accelerates wound closure via the upregulation of mtROS and Cytochrome P450. Our results reveal how mitochondrial dynamics respond to cellular and tissue injury and promote tissue repair.

Date: 2020
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DOI: 10.1038/s41467-020-14885-x

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