Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life

Melanie R. Neeland (), Sandra Andorf, Monali Manohar, Diane Dunham, Shu-Chen Lyu, Thanh D. Dang, Rachel L. Peters, Kirsten P. Perrett, Mimi L. K. Tang, Richard Saffery, Jennifer J. Koplin and Kari C. Nadeau ()
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Melanie R. Neeland: Murdoch Children’s Research Institute
Sandra Andorf: Sean N. Parker Center for Allergy and Asthma Research at Stanford University
Monali Manohar: Sean N. Parker Center for Allergy and Asthma Research at Stanford University
Diane Dunham: Sean N. Parker Center for Allergy and Asthma Research at Stanford University
Shu-Chen Lyu: Sean N. Parker Center for Allergy and Asthma Research at Stanford University
Thanh D. Dang: Murdoch Children’s Research Institute
Rachel L. Peters: Murdoch Children’s Research Institute
Kirsten P. Perrett: Murdoch Children’s Research Institute
Mimi L. K. Tang: Murdoch Children’s Research Institute
Richard Saffery: Murdoch Children’s Research Institute
Jennifer J. Koplin: Murdoch Children’s Research Institute
Kari C. Nadeau: Sean N. Parker Center for Allergy and Asthma Research at Stanford University

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract IgE-mediated peanut allergic is common, often serious, and usually lifelong. Not all individuals who produce peanut-specific IgE will react upon consumption of peanut and can eat the food without adverse reactions, known as sensitized tolerance. Here, we employ high-dimensional mass cytometry to define the circulating immune cell signatures associated with sensitized tolerance and clinical allergy to peanut in the first year of life. Key features of clinical peanut allergic are increased frequency of activated B cells (CD19hiHLADRhi), overproduction of TNFα and increased frequency of peanut-specific memory CD4 T cells. Infants with sensitized tolerance display reduced frequency but hyper-responsive naive CD4 T cells and an increased frequency of plasmacytoid dendritic cells. This work demonstrates the utility and power of high-dimensional mass cytometry analysis to interrogate the cellular interactions that are associated with allergic sensitization and clinical food allergy in the first year of life.

Date: 2020
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DOI: 10.1038/s41467-020-14919-4

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