Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light

Gi Byoung Hwang, He Huang, Gaowei Wu, Juhun Shin, Andreas Kafizas, Kersti Karu, Hendrik Du Toit, Abdullah M. Alotaibi, Layla Mohammad-Hadi, Elaine Allan, Alexander J. MacRobert, Asterios Gavriilidis and Ivan P. Parkin ()
Additional contact information
Gi Byoung Hwang: University College London
He Huang: University College London
Gaowei Wu: University College London
Juhun Shin: University College London
Andreas Kafizas: Imperial College London, Molecular Science Research Hub, White City Campus
Kersti Karu: University College London
Hendrik Du Toit: University College London
Abdullah M. Alotaibi: University College London
Layla Mohammad-Hadi: UCL Division of Surgery and Interventional Science, Royal Free Campus
Elaine Allan: University College London
Alexander J. MacRobert: UCL Division of Surgery and Interventional Science, Royal Free Campus
Asterios Gavriilidis: University College London
Ivan P. Parkin: University College London

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light source or UV-activation is usually required. Here we report a photobactericidal polymer containing crystal violet (CV) and thiolated gold nanocluster ([Au25(Cys)18]) activated at a low flux levels of white light. It was shown that the polymer encapsulated with CV do not have photobactericidal activity under white light illumination of an average 312 lux. However, encapsulation of [Au25(Cys)18] and CV into the polymer activates potent photobactericidal activity. The study of the photobactericidal mechanism shows that additional encapsulation of [Au25(Cys)18] into the CV treated polymer promotes redox reactions through generation of alternative electron transfer pathways, while it reduces photochemical reaction type-ІІ pathways resulting in promotion of hydrogen peroxide (H2O2) production.

Date: 2020
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DOI: 10.1038/s41467-020-15004-6

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