Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy

Wei Zhang, Li Xu, Hae-Bin Park, Juyoung Hwang, Minseok Kwak, Peter C. W. Lee, Guang Liang, Xiaoyan Zhang, Jianqing Xu and Jun-O Jin ()
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Wei Zhang: Fudan University
Li Xu: Fudan University
Hae-Bin Park: Fudan University
Juyoung Hwang: Fudan University
Minseok Kwak: Pukyong National University
Peter C. W. Lee: University of Ulsan College of Medicine, ASAN Medical Center
Guang Liang: Wenzhou Medical University, Wenzhou
Xiaoyan Zhang: Fudan University
Jianqing Xu: Fudan University
Jun-O Jin: Fudan University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Induction of antigen-specific immune activation by the maturation of dendritic cells (DCs) is a strategy used for cancer immunotherapy. In this study, we find that FimH, which is an Escherichia coli adhesion portion, induces toll-like receptor 4-dependent and myeloid differentiation protein 2-independent DC maturation in mice in vivo. A combined treatment regimen with FimH and antigen promotes antigen-specific immune activation, including proliferation of T cells, production of IFN-γ and TNF-α, and infiltration of effector T cells into tumors, which consequently inhibits tumor growth in mice in vivo against melanoma and carcinoma. In addition, combined therapeutic treatment of anti-PD-L1 antibodies and FimH treatment efficiently inhibits CT26 tumor growth in BALB/c mice. Finally, FimH promotes human peripheral blood DC activation and syngeneic T-cell proliferation and activation. Taken together, these findings demonstrate that FimH can be a useful adjuvant for cancer immunotherapy.

Date: 2020
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DOI: 10.1038/s41467-020-15030-4

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