Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Xiang Shu, Jirong Long, Qiuyin Cai, Sun-Seog Kweon, Ji-Yeob Choi, Michiaki Kubo, Sue K. Park, Manjeet K. Bolla, Joe Dennis, Qin Wang, Yaohua Yang, Jiajun Shi, Xingyi Guo, Bingshan Li, Ran Tao, Kristan J. Aronson, Kelvin Y. K. Chan, Tsun L. Chan, Yu-Tang Gao, Mikael Hartman, Weang Kee Ho, Hidemi Ito, Motoki Iwasaki, Hiroji Iwata, Esther M. John, Yoshio Kasuga, Ui Soon Khoo, Mi-Kyung Kim, Sun-Young Kong, Allison W. Kurian, Ava Kwong, Eun-Sook Lee, Jingmei Li, Artitaya Lophatananon, Siew-Kee Low, Shivaani Mariapun, Koichi Matsuda, Keitaro Matsuo, Kenneth Muir, Dong-Young Noh, Boyoung Park, Min-Ho Park, Chen-Yang Shen, Min-Ho Shin, John J. Spinelli, Atsushi Takahashi, Chiuchen Tseng, Shoichiro Tsugane, Anna H. Wu, Yong-Bing Xiang, Taiki Yamaji, Ying Zheng, Roger L. Milne, Alison M. Dunning, Paul D. P. Pharoah, Montserrat García-Closas, Soo-Hwang Teo, Xiao-ou Shu, Daehee Kang, Douglas F. Easton, Jacques Simard and Wei Zheng ()
Additional contact information
Xiang Shu: Vanderbilt University Medical Center
Jirong Long: Vanderbilt University Medical Center
Qiuyin Cai: Vanderbilt University Medical Center
Sun-Seog Kweon: Chonnam National University Medical School
Ji-Yeob Choi: Seoul National University College of Medicine
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Sue K. Park: Seoul National University College of Medicine
Manjeet K. Bolla: University of Cambridge
Joe Dennis: University of Cambridge
Qin Wang: University of Cambridge
Yaohua Yang: Vanderbilt University Medical Center
Jiajun Shi: Vanderbilt University Medical Center
Xingyi Guo: Vanderbilt University Medical Center
Bingshan Li: Vanderbilt Genetics Institute, Vanderbilt University
Ran Tao: Vanderbilt University Medical Center
Kristan J. Aronson: Queen’s University
Kelvin Y. K. Chan: University of Hong Kong
Tsun L. Chan: Hong Kong Hereditary Breast Cancer Family Registry
Yu-Tang Gao: Shanghai Jiaotong University School of Medicine
Mikael Hartman: National University Hospital
Weang Kee Ho: University of Nottingham Malaysia Campus
Hidemi Ito: Aichi Cancer Center Research Institute
Motoki Iwasaki: Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
Hiroji Iwata: Aichi Cancer Center
Esther M. John: Cancer Prevention Institute of California
Yoshio Kasuga: Nagano Matsushiro General Hospital
Ui Soon Khoo: University of Hong Kong
Mi-Kyung Kim: Division of Cancer Epidemiology and Management, National Cancer Center
Sun-Young Kong: National Cancer Center Graduate School of Cancer Science and Policy
Allison W. Kurian: School of Medicine, Stanford University
Ava Kwong: Hong Kong Hereditary Breast Cancer Family Registry
Eun-Sook Lee: National Cancer Center Graduate School of Cancer Science and Policy
Jingmei Li: National University of Singapore
Artitaya Lophatananon: Warwick University
Siew-Kee Low: RIKEN Center for Integrative Medical Sciences
Shivaani Mariapun: Cancer Research Malaysia
Koichi Matsuda: University of Tokyo
Keitaro Matsuo: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
Kenneth Muir: Warwick University
Dong-Young Noh: Cancer Research Institute, Seoul National University College of Medicine
Boyoung Park: Hanyang University College of Medicine
Min-Ho Park: Chonnam National University Medical School
Chen-Yang Shen: China Medical University
Min-Ho Shin: Chonnam National University Medical School
John J. Spinelli: Population Oncology, BC Cancer
Atsushi Takahashi: RIKEN Center for Integrative Medical Sciences
Chiuchen Tseng: University of Southern California
Shoichiro Tsugane: National Cancer Center
Anna H. Wu: University of Southern California
Yong-Bing Xiang: Shanghai Jiaotong University School of Medicine
Taiki Yamaji: Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
Ying Zheng: Shanghai Municipal Center for Disease Control and Prevention
Roger L. Milne: Cancer Epidemiology Division, Cancer Council Victoria
Alison M. Dunning: University of Cambridge
Paul D. P. Pharoah: University of Cambridge
Montserrat García-Closas: National Cancer Institute
Soo-Hwang Teo: Cancer Research Malaysia
Xiao-ou Shu: Vanderbilt University Medical Center
Daehee Kang: Seoul National University College of Medicine
Douglas F. Easton: University of Cambridge
Jacques Simard: Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center
Wei Zheng: Vanderbilt University Medical Center

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P

Date: 2020
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DOI: 10.1038/s41467-020-15046-w

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