Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Yuanyuan Li, Zhaochong Cai, Shunjie Liu, Haoke Zhang, Sherman T. H. Wong, Jacky W. Y. Lam, Ryan T. K. Kwok, Jun Qian () and Ben Zhong Tang ()
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Yuanyuan Li: The Hong Kong University of Science and Technology
Zhaochong Cai: Zhejiang University
Shunjie Liu: The Hong Kong University of Science and Technology
Haoke Zhang: The Hong Kong University of Science and Technology
Sherman T. H. Wong: The Hong Kong University of Science and Technology
Jacky W. Y. Lam: The Hong Kong University of Science and Technology
Ryan T. K. Kwok: The Hong Kong University of Science and Technology
Jun Qian: Zhejiang University
Ben Zhong Tang: The Hong Kong University of Science and Technology

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging.

Date: 2020
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DOI: 10.1038/s41467-020-15095-1

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