The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Matthias I. Gröschel, Conor J. Meehan, Ivan Barilar, Margo Diricks, Aitor Gonzaga, Matthias Steglich, Oscar Conchillo-Solé, Isabell-Christin Scherer, Uwe Mamat, Christian F. Luz, Katrien Bruyne, Christian Utpatel, Daniel Yero, Isidre Gibert, Xavier Daura, Stefanie Kampmeier, Nurdyana Abdul Rahman, Michael Kresken, Tjip S. Werf, Ifey Alio, Wolfgang R. Streit, Kai Zhou, Thomas Schwartz, John W. A. Rossen, Maha R. Farhat, Ulrich E. Schaible, Ulrich Nübel, Jan Rupp, Joerg Steinmann, Stefan Niemann () and Thomas A. Kohl
Additional contact information
Matthias I. Gröschel: Molecular and Experimental Mycobacteriology, Research Center Borstel
Conor J. Meehan: School of Chemistry and Bioscience, University of Bradford
Ivan Barilar: Molecular and Experimental Mycobacteriology, Research Center Borstel
Margo Diricks: bioMérieux, Applied Maths NV, Keistraat 120
Aitor Gonzaga: Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures
Matthias Steglich: Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures
Oscar Conchillo-Solé: Universitat Autònoma de Barcelona
Isabell-Christin Scherer: University Hospital Schleswig-Holstein
Uwe Mamat: Cellular Microbiology, Research Center Borstel
Christian F. Luz: University Medical Center Groningen, University of Groningen
Katrien Bruyne: bioMérieux, Applied Maths NV, Keistraat 120
Christian Utpatel: Molecular and Experimental Mycobacteriology, Research Center Borstel
Daniel Yero: Universitat Autònoma de Barcelona
Isidre Gibert: Universitat Autònoma de Barcelona
Xavier Daura: Universitat Autònoma de Barcelona
Stefanie Kampmeier: University Hospital Münster
Nurdyana Abdul Rahman: Singapore General Hospital
Michael Kresken: Antiinfectives Intelligence GmbH
Tjip S. Werf: University Medical Center Groningen, University of Groningen
Ifey Alio: University of Hamburg
Wolfgang R. Streit: University of Hamburg
Kai Zhou: Southern University of Science and Technology
Thomas Schwartz: Karlsruhe Institute of Technology, Institute of Functional Interfaces
John W. A. Rossen: University Medical Center Groningen, University of Groningen
Maha R. Farhat: Department of Biomedical Informatics, Harvard Medical School
Ulrich E. Schaible: Cellular Microbiology, Research Center Borstel
Ulrich Nübel: Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures
Jan Rupp: University Hospital Schleswig-Holstein
Joerg Steinmann: University Medical Center Essen
Stefan Niemann: Molecular and Experimental Mycobacteriology, Research Center Borstel
Thomas A. Kohl: Molecular and Experimental Mycobacteriology, Research Center Borstel

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.

Date: 2020
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DOI: 10.1038/s41467-020-15123-0

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