Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins

Stefan Roberts, Vincent Miao, Simone Costa, Joseph Simon, Garrett Kelly, Tejank Shah, Stefan Zauscher and Ashutosh Chilkoti ()
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Stefan Roberts: Duke University
Vincent Miao: Duke University
Simone Costa: Duke University
Joseph Simon: Duke University
Garrett Kelly: Duke University
Tejank Shah: Duke University
Stefan Zauscher: Duke University
Ashutosh Chilkoti: Duke University

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract The controllable production of microparticles with complex geometries is useful for a variety of applications in materials science and bioengineering. The formation of intricate microarchitectures typically requires sophisticated fabrication techniques such as flow lithography or multiple-emulsion microfluidics. By harnessing the molecular interactions of a set of artificial intrinsically disordered proteins (IDPs), we have created complex microparticle geometries, including porous particles, core-shell and hollow shell structures, and a unique ‘fruits-on-a-vine’ arrangement, by exploiting the metastable region of the phase diagram of thermally responsive IDPs within microdroplets. Through multi-site unnatural amino acid (UAA) incorporation, these protein microparticles can also be photo-crosslinked and stably extracted to an all-aqueous environment. This work expands the functional utility of artificial IDPs as well as the available microarchitectures of this class of biocompatible IDPs, with potential applications in drug delivery and tissue engineering.

Date: 2020
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DOI: 10.1038/s41467-020-15128-9

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