Bisphosphonate nanoclay edge-site interactions facilitate hydrogel self-assembly and sustained growth factor localization

Yang-Hee Kim, Xia Yang, Liyang Shi, Stuart A. Lanham, Jons Hilborn, Richard O. C. Oreffo, Dmitri Ossipov () and Jonathan I. Dawson ()
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Yang-Hee Kim: University of Southampton
Xia Yang: Uppsala University
Liyang Shi: Uppsala University
Stuart A. Lanham: University of Southampton
Jons Hilborn: Uppsala University
Richard O. C. Oreffo: University of Southampton
Dmitri Ossipov: H2, Karolinska Institute 141 83
Jonathan I. Dawson: University of Southampton

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Nanoclays have generated interest in biomaterial design for their ability to enhance the mechanics of polymeric materials and impart biological function. As well as their utility as physical cross-linkers, clays have been explored for sustained localization of biomolecules to promote in vivo tissue regeneration. To date, both biomolecule-clay and polymer-clay nanocomposite strategies have utilised the negatively charged clay particle surface. As such, biomolecule-clay and polymer-clay interactions are set in competition, potentially limiting the functional enhancements achieved. Here, we apply specific bisphosphonate interactions with the positively charged clay particle edge to develop self-assembling hydrogels and functionalized clay nanoparticles with preserved surface exchange capacity. Low concentrations of nanoclay are applied to cross-link hyaluronic acid polymers derivatised with a pendant bisphosphonate to generate hydrogels with enhanced mechanical properties and preserved protein binding able to sustain, for over six weeks in vivo, the localized activity of the clinically licensed growth factor BMP-2.

Date: 2020
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DOI: 10.1038/s41467-020-15152-9

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