FAM13A affects body fat distribution and adipocyte function

Mohsen Fathzadeh, Jiehan Li, Abhiram Rao, Naomi Cook, Indumathi Chennamsetty, Marcus Seldin, Xiang Zhou, Panjamaporn Sangwung, Michael J. Gloudemans, Mark Keller, Allan Attie, Jing Yang, Martin Wabitsch, Ivan Carcamo-Orive, Yuko Tada, Aldons J. Lusis, Myung Kyun Shin, Cliona M. Molony, Tracey McLaughlin, Gerald Reaven, Stephen B. Montgomery, Dermot Reilly, Thomas Quertermous, Erik Ingelsson () and Joshua W. Knowles ()
Additional contact information
Mohsen Fathzadeh: Stanford University School of Medicine
Jiehan Li: Stanford University School of Medicine
Abhiram Rao: Stanford University School of Medicine
Naomi Cook: Uppsala University
Indumathi Chennamsetty: Stanford University School of Medicine
Marcus Seldin: David Geffen School of Medicine, UCLA
Xiang Zhou: Stanford University School of Medicine
Panjamaporn Sangwung: Stanford University School of Medicine
Michael J. Gloudemans: Stanford University
Mark Keller: University of Wisconsin
Allan Attie: University of Wisconsin
Jing Yang: University of Illinois at Urbana–Champaign
Martin Wabitsch: University of Ulm
Ivan Carcamo-Orive: Stanford University School of Medicine
Yuko Tada: Stanford University School of Medicine
Aldons J. Lusis: David Geffen School of Medicine, UCLA
Myung Kyun Shin: Genetics and Pharmacogenomics, Merck & Co., Inc.
Cliona M. Molony: Genetics and Pharmacogenomics, Merck & Co., Inc.
Tracey McLaughlin: Stanford University
Gerald Reaven: Stanford University School of Medicine
Stephen B. Montgomery: Stanford University
Dermot Reilly: Genetics and Pharmacogenomics, Merck & Co., Inc.
Thomas Quertermous: Stanford University School of Medicine
Erik Ingelsson: Stanford University School of Medicine
Joshua W. Knowles: Stanford University School of Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting insulin levels, but lower body fat). In human adipocyte models, knockdown of FAM13A in preadipocytes accelerates adipocyte differentiation. In mice, Fam13a knockout (KO) have a lower visceral to subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge, in comparison to their wild-type counterparts. Subcutaneous adipocytes in KO mice show a size distribution shift toward an increased number of smaller adipocytes, along with an improved adipogenic potential. Our results indicate that GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-15291-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15291-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-15291-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().