Nitric oxide as a source for bacterial triazole biosynthesis

Guiyun Zhao, Yuan-Yang Guo, Shunyu Yao, Xinjie Shi, Longxian Lv and Yi-Ling Du ()
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Guiyun Zhao: Zhejiang University School of Medicine
Yuan-Yang Guo: Henan Normal University
Shunyu Yao: Zhejiang University School of Medicine
Xinjie Shi: Zhejiang University School of Medicine
Longxian Lv: Zhejiang University
Yi-Ling Du: Zhejiang University School of Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract The heterocycle 1,2,3-triazole is among the most versatile chemical scaffolds and has been widely used in diverse fields. However, how nature creates this nitrogen-rich ring system remains unknown. Here, we report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine. We reveal that its triazole moiety can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is used as a building block. These results expand our knowledge of the physiological role of nitric oxide synthase in building natural products with a nitrogen–nitrogen bond, and should also inspire the development of synthetic biology approaches for triazole production.

Date: 2020
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DOI: 10.1038/s41467-020-15420-8

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