Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

Joana A. Revez, Tian Lin, Zhen Qiao, Angli Xue, Yan Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, Julia Sidorenko, Kathryn E. Kemper, Anna A. E. Vinkhuyzen, Julanne Frater, Darryl Eyles, Thomas H. J. Burne, Brittany Mitchell, Nicholas G. Martin, Gu Zhu, Peter M. Visscher, Jian Yang, Naomi R. Wray () and John J. McGrath ()
Additional contact information
Joana A. Revez: The University of Queensland
Tian Lin: The University of Queensland
Zhen Qiao: The University of Queensland
Angli Xue: The University of Queensland
Yan Holtz: The University of Queensland
Zhihong Zhu: The University of Queensland
Jian Zeng: The University of Queensland
Huanwei Wang: The University of Queensland
Julia Sidorenko: The University of Queensland
Kathryn E. Kemper: The University of Queensland
Anna A. E. Vinkhuyzen: The University of Queensland
Julanne Frater: The University of Queensland
Darryl Eyles: The University of Queensland
Thomas H. J. Burne: The University of Queensland
Brittany Mitchell: QIMR Berghofer Medical Research Institute
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Gu Zhu: QIMR Berghofer Medical Research Institute
Peter M. Visscher: The University of Queensland
Jian Yang: The University of Queensland
Naomi R. Wray: The University of Queensland
John J. McGrath: The University of Queensland

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this study.

Date: 2020
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DOI: 10.1038/s41467-020-15421-7

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