In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy

Yannan Liu, Hao Wang, Shanlong Li, Chuanshuang Chen, Li Xu, Ping Huang, Feng Liu, Yue Su, Meiwei Qi, Chunyang Yu and Yongfeng Zhou ()
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Yannan Liu: Shanghai Jiao Tong University
Hao Wang: Shenzhen University
Shanlong Li: Shanghai Jiao Tong University
Chuanshuang Chen: Shanghai Jiao Tong University
Li Xu: Shanghai Jiao Tong University
Ping Huang: Shanghai Jiao Tong University
Feng Liu: Shanghai Jiao Tong University
Yue Su: Shanghai Jiao Tong University
Meiwei Qi: Shanghai Jiao Tong University
Chunyang Yu: Shanghai Jiao Tong University
Yongfeng Zhou: Shanghai Jiao Tong University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have seldom been used as PTAs due to the unsatisfactory photothermal conversion efficiency resulting from the irregular packing of chromophores in the vesicle membranes. Here we report a nano-sized polymer vesicle from hyperbranched polyporphyrins with favorable photothermal stability and extraordinarily high photothermal efficiency (44.1%), showing great potential in imaging-guided PTT for tumors through in vitro and in vivo experiments. These excellent properties are attributed to the in situ supramolecular polymerization of porphyrin units inside the vesicle membrane into well-organized 1D monofilaments driven by π–π stacking. We believe the supramolecular polymerization-enhanced self-assembly process reported here will shed a new light on the design of supramolecular materials with new structures and functions.

Date: 2020
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DOI: 10.1038/s41467-020-15427-1

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