Metagenome-wide association of gut microbiome features for schizophrenia

Feng Zhu, Yanmei Ju, Wei Wang, Qi Wang, Ruijin Guo, Qingyan Ma, Qiang Sun, Yajuan Fan, Yuying Xie, Zai Yang, Zhuye Jie, Binbin Zhao, Liang Xiao, Lin Yang, Tao Zhang, Junqin Feng, Liyang Guo, Xiaoyan He, Yunchun Chen, Ce Chen, Chengge Gao, Xun Xu, Huanming Yang, Jian Wang, Yonghui Dang, Lise Madsen, Susanne Brix, Karsten Kristiansen (), Huijue Jia () and Xiancang Ma ()
Additional contact information
Feng Zhu: The First Affiliated Hospital of Xi’an Jiaotong University
Yanmei Ju: BGI-Shenzhen
Wei Wang: The First Affiliated Hospital of Xi’an Jiaotong University
Qi Wang: BGI-Shenzhen
Ruijin Guo: BGI-Shenzhen
Qingyan Ma: The First Affiliated Hospital of Xi’an Jiaotong University
Qiang Sun: BGI-Shenzhen
Yajuan Fan: The First Affiliated Hospital of Xi’an Jiaotong University
Yuying Xie: Michigan State University
Zai Yang: The First Affiliated Hospital of Xi’an Jiaotong University
Zhuye Jie: BGI-Shenzhen
Binbin Zhao: The First Affiliated Hospital of Xi’an Jiaotong University
Liang Xiao: BGI-Shenzhen
Lin Yang: The First Affiliated Hospital of Xi’an Jiaotong University
Tao Zhang: BGI-Shenzhen
Junqin Feng: The First Affiliated Hospital of Xi’an Jiaotong University
Liyang Guo: The First Affiliated Hospital of Xi’an Jiaotong University
Xiaoyan He: The First Affiliated Hospital of Xi’an Jiaotong University
Yunchun Chen: The First Affiliated Hospital of Xi’an Jiaotong University
Ce Chen: The First Affiliated Hospital of Xi’an Jiaotong University
Chengge Gao: The First Affiliated Hospital of Xi’an Jiaotong University
Xun Xu: BGI-Shenzhen
Huanming Yang: BGI-Shenzhen
Jian Wang: BGI-Shenzhen
Yonghui Dang: Xi’an Jiaotong University
Lise Madsen: BGI-Shenzhen
Susanne Brix: BGI-Shenzhen
Karsten Kristiansen: BGI-Shenzhen
Huijue Jia: BGI-Shenzhen
Xiancang Ma: The First Affiliated Hospital of Xi’an Jiaotong University

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.

Date: 2020
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DOI: 10.1038/s41467-020-15457-9

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