Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes

Deepak N. Subramanian, Magnus Zethoven, Simone McInerny, James A. Morgan, Simone M. Rowley, Jue Er Amanda Lee, Na Li, Kylie L. Gorringe, Paul A. James and Ian G. Campbell ()
Additional contact information
Deepak N. Subramanian: Peter MacCallum Cancer Centre
Magnus Zethoven: Peter MacCallum Cancer Centre
Simone McInerny: Peter MacCallum Cancer Centre and The Royal Melbourne Hospital
James A. Morgan: Peter MacCallum Cancer Centre and The Royal Melbourne Hospital
Simone M. Rowley: Peter MacCallum Cancer Centre
Jue Er Amanda Lee: Peter MacCallum Cancer Centre
Na Li: Peter MacCallum Cancer Centre
Kylie L. Gorringe: The University of Melbourne
Paul A. James: Peter MacCallum Cancer Centre
Ian G. Campbell: Peter MacCallum Cancer Centre

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, approximately half of which cannot be explained by known genes. To discover genes, we analyse germline exome sequencing data from 516 BRCA1/2-negative women with HGSOC, focusing on genes enriched with rare, protein-coding loss-of-function (LoF) variants. Overall, there is a significant enrichment of rare protein-coding LoF variants in the cases (p

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-15461-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15461-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-15461-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().