Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Wei Xu, Lin Wang, Ru Zhang, Xuming Sun, Lin Huang, Haiyang Su, Xunbin Wei, Chia-Chun Chen, Jiatao Lou (), Hongjie Dai and Kun Qian ()
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Wei Xu: Shanghai Jiao Tong University
Lin Wang: Shanghai Jiao Tong University
Ru Zhang: Shanghai Jiao Tong University
Xuming Sun: Shanghai Jiao Tong University
Lin Huang: Shanghai Jiao Tong University
Haiyang Su: Shanghai Jiao Tong University
Xunbin Wei: Shanghai Jiao Tong University
Chia-Chun Chen: National Taiwan Normal University
Jiatao Lou: Shanghai Jiao Tong University
Hongjie Dai: Stanford University
Kun Qian: Shanghai Jiao Tong University

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing.

Date: 2020
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DOI: 10.1038/s41467-020-15487-3

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