Pre-clinical modeling of cutaneous melanoma

Vito W. Rebecca, Rajasekharan Somasundaram and Meenhard Herlyn ()
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Vito W. Rebecca: Melanoma Research Center
Rajasekharan Somasundaram: Melanoma Research Center
Meenhard Herlyn: Melanoma Research Center

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes melanoma as an ideal model for investigating therapy resistance. In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft. In particular, we highlight how each system recapitulates different features of melanoma adaptability and can be used to better understand melanoma development, progression and therapy resistance.

Date: 2020
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DOI: 10.1038/s41467-020-15546-9

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