Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

Yordi J. Vegte, M. Abdullah Said, Michiel Rienstra, Pim Harst () and Niek Verweij ()
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Yordi J. Vegte: University of Groningen, University Medical Center Groningen
M. Abdullah Said: University of Groningen, University Medical Center Groningen
Michiel Rienstra: University of Groningen, University Medical Center Groningen
Pim Harst: University of Groningen, University Medical Center Groningen
Niek Verweij: University of Groningen, University Medical Center Groningen

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronary artery disease (CAD). Genome wide association analyses of leisure television watching, leisure computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci (P

Date: 2020
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DOI: 10.1038/s41467-020-15553-w

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