Synthetic hybrids of six yeast species

David Peris (), William G. Alexander, Kaitlin J. Fisher, Ryan V. Moriarty, Mira G. Basuino, Emily J. Ubbelohde, Russell L. Wrobel and Chris Todd Hittinger ()
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David Peris: University of Wisconsin-Madison
William G. Alexander: University of Wisconsin-Madison
Kaitlin J. Fisher: University of Wisconsin-Madison
Ryan V. Moriarty: University of Wisconsin-Madison
Mira G. Basuino: Truman State University
Emily J. Ubbelohde: Truman State University
Russell L. Wrobel: University of Wisconsin-Madison
Chris Todd Hittinger: University of Wisconsin-Madison

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Allopolyploidy generates diversity by increasing the number of copies and sources of chromosomes. Many of the best-known evolutionary radiations, crops, and industrial organisms are ancient or recent allopolyploids. Allopolyploidy promotes differentiation and facilitates adaptation to new environments, but the tools to test its limits are lacking. Here we develop an iterative method of Hybrid Production (iHyPr) to combine the genomes of multiple budding yeast species, generating Saccharomyces allopolyploids of at least six species. When making synthetic hybrids, chromosomal instability and cell size increase dramatically as additional copies of the genome are added. The six-species hybrids initially grow slowly, but they rapidly regain fitness and adapt, even as they retain traits from multiple species. These new synthetic yeast hybrids and the iHyPr method have potential applications for the study of polyploidy, genome stability, chromosome segregation, and bioenergy.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15559-4

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DOI: 10.1038/s41467-020-15559-4

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