A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

Jungyoon Kim, Sujung Yoon, Suji Lee, Haejin Hong, Eunji Ha, Yoonji Joo, Eun Hee Lee and In Kyoon Lyoo ()
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Jungyoon Kim: Ewha Brain Institute, Ewha Womans University
Sujung Yoon: Ewha Brain Institute, Ewha Womans University
Suji Lee: Ewha Brain Institute, Ewha Womans University
Haejin Hong: Ewha Brain Institute, Ewha Womans University
Eunji Ha: Ewha Brain Institute, Ewha Womans University
Yoonji Joo: Ewha Brain Institute, Ewha Womans University
Eun Hee Lee: Green Cross Laboratories
In Kyoon Lyoo: Ewha Brain Institute, Ewha Womans University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Growing evidence indicates a reciprocal relationship between low-grade systemic inflammation and stress exposure towards increased vulnerability to neuropsychiatric disorders, including posttraumatic stress disorder (PTSD). However, the neural correlates of this reciprocity and their influence on the subsequent development of PTSD are largely unknown. Here we investigated alterations in functional connectivity among brain networks related to low-grade inflammation and stress exposure using two large independent data sets. Functional couplings among the higher-order cognitive network system including the salience, default mode, and central executive networks were reduced in association with low-grade inflammation and stress exposure. This reduced functional coupling may also be related to subsequent posttraumatic stress symptom severity. The current findings propose functional couplings among the higher-order cognitive network system as neural correlates of low-grade inflammation and stress exposure, and suggest that low-grade inflammation, alongside with stress, may render individuals more vulnerable to PTSD.

Date: 2020
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DOI: 10.1038/s41467-020-15655-5

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