Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Kay H. M. Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, Esther Phielix, Bas Havekes, Yvonne M. H. Bruls, Martijn C. G. J. Brouwers, Marcus Ståhlman, Marjan Alssema, Harry P. F. Peters, Renée Mutsert, Bart Staels, Marja-Riitta Taskinen, Jan Borén, Patrick Schrauwen and Vera B. Schrauwen-Hinderling ()
Additional contact information
Kay H. M. Roumans: Maastricht University
Lucas Lindeboom: Maastricht University
Pandichelvam Veeraiah: Maastricht University
Carlijn M. E. Remie: Maastricht University
Esther Phielix: Maastricht University
Bas Havekes: Maastricht University Medical Center
Yvonne M. H. Bruls: Maastricht University
Martijn C. G. J. Brouwers: Maastricht University Medical Center
Marcus Ståhlman: University of Gothenburg, and Sahlgrenska University Hospital
Marjan Alssema: Unilever Food Innovation Center
Harry P. F. Peters: Unilever Food Innovation Center
Renée Mutsert: Leiden University Medical Center
Bart Staels: Institut Pasteur de Lille
Marja-Riitta Taskinen: University of Helsinki
Jan Borén: University of Gothenburg, and Sahlgrenska University Hospital
Patrick Schrauwen: Maastricht University
Vera B. Schrauwen-Hinderling: Maastricht University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.

Date: 2020
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DOI: 10.1038/s41467-020-15684-0

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