Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Fanlei Hu (), Xiang Jiang, Chunqing Guo, Yingni Li, Shixian Chen, Wei Zhang, Yan Du, Ping Wang, Xi Zheng, Xiangyu Fang, Xin Li, Jing Song, Yang Xie, Fei Huang, Jimeng Xue, Mingxin Bai, Yuan Jia, Xu Liu, Limin Ren, Xiaoying Zhang, Jianping Guo, Hudan Pan, Yin Su, Huanfa Yi, Hua Ye, Daming Zuo, Juan Li, Huaxiang Wu, Yongfu Wang, Ru Li, Liang Liu (), Xiang-Yang Wang () and Zhanguo Li ()
Additional contact information
Fanlei Hu: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Xiang Jiang: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Chunqing Guo: Virginia Commonwealth University, School of Medicine
Yingni Li: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Shixian Chen: Southern Medical University
Wei Zhang: First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity
Yan Du: Zhejiang University School of Medicine
Ping Wang: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Xi Zheng: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Xiangyu Fang: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Xin Li: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Jing Song: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Yang Xie: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Fei Huang: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Jimeng Xue: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Mingxin Bai: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Yuan Jia: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Xu Liu: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Limin Ren: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Xiaoying Zhang: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Jianping Guo: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Hudan Pan: Macau University of Science and Technology
Yin Su: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Huanfa Yi: Virginia Commonwealth University, School of Medicine
Hua Ye: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Daming Zuo: Virginia Commonwealth University, School of Medicine
Juan Li: Southern Medical University
Huaxiang Wu: Zhejiang University School of Medicine
Yongfu Wang: First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of Autoimmunity
Ru Li: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)
Liang Liu: Macau University of Science and Technology
Xiang-Yang Wang: Virginia Commonwealth University, School of Medicine
Zhanguo Li: Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.

Date: 2020
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DOI: 10.1038/s41467-020-15700-3

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