Repurposing a chemosensory macromolecular machine

Davi R. Ortega, Wen Yang, Poorna Subramanian, Petra Mann, Andreas Kjær, Songye Chen, Kylie J. Watts, Sahand Pirbadian, David A. Collins, Romain Kooger, Marina G. Kalyuzhnaya, Simon Ringgaard, Ariane Briegel () and Grant J. Jensen ()
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Davi R. Ortega: California Institute of Technology
Wen Yang: Institute of Biology, Leiden University
Poorna Subramanian: California Institute of Technology
Petra Mann: Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology
Andreas Kjær: California Institute of Technology
Songye Chen: California Institute of Technology
Kylie J. Watts: Division of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University
Sahand Pirbadian: University of Southern California
David A. Collins: Viral Information Institute, San Diego State University
Romain Kooger: Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule Zürich
Marina G. Kalyuzhnaya: Viral Information Institute, San Diego State University
Simon Ringgaard: Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology
Ariane Briegel: Institute of Biology, Leiden University
Grant J. Jensen: California Institute of Technology

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract How complex, multi-component macromolecular machines evolved remains poorly understood. Here we reveal the evolutionary origins of the chemosensory machinery that controls flagellar motility in Escherichia coli. We first identify ancestral forms still present in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis and Methylomicrobium alcaliphilum, characterizing their structures by electron cryotomography and finding evidence that they function in a stress response pathway. Using bioinformatics, we trace the evolution of the system through γ-Proteobacteria, pinpointing key evolutionary events that led to the machine now seen in E. coli. Our results suggest that two ancient chemosensory systems with different inputs and outputs (F6 and F7) existed contemporaneously, with one (F7) ultimately taking over the inputs and outputs of the other (F6), which was subsequently lost.

Date: 2020
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DOI: 10.1038/s41467-020-15736-5

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