A single-cell transcriptomic landscape of primate arterial aging

Weiqi Zhang, Shu Zhang, Pengze Yan, Jie Ren, Moshi Song, Jingyi Li, Jinghui Lei, Huize Pan, Si Wang, Xibo Ma, Shuai Ma, Hongyu Li, Fei Sun, Haifeng Wan, Wei Li, Piu Chan, Qi Zhou, Guang-Hui Liu (), Fuchou Tang () and Jing Qu ()
Additional contact information
Weiqi Zhang: Beijing Institute of Genomics, Chinese Academy of Sciences
Shu Zhang: Peking University
Pengze Yan: University of Chinese Academy of Sciences
Jie Ren: Peking University
Moshi Song: University of Chinese Academy of Sciences
Jingyi Li: Chinese Academy of Sciences
Jinghui Lei: Xuanwu Hospital Capital Medical University
Huize Pan: Chinese Academy of Sciences
Si Wang: University of Chinese Academy of Sciences
Xibo Ma: University of Chinese Academy of Sciences
Shuai Ma: Chinese Academy of Sciences
Hongyu Li: Chinese Academy of Sciences
Fei Sun: Chinese Academy of Sciences
Haifeng Wan: University of Chinese Academy of Sciences
Wei Li: University of Chinese Academy of Sciences
Piu Chan: Xuanwu Hospital Capital Medical University
Qi Zhou: University of Chinese Academy of Sciences
Guang-Hui Liu: Chinese Academy of Sciences
Fuchou Tang: Peking University
Jing Qu: University of Chinese Academy of Sciences

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited. Here we report a single-cell transcriptomic survey of aortas and coronary arteries in young and old cynomolgus monkeys. Our data define the molecular signatures of specialized arteries and identify eight markers discriminating aortic and coronary vasculatures. Gene network analyses characterize transcriptional landmarks that regulate vascular senility and position FOXO3A, a longevity-associated transcription factor, as a master regulator gene that is downregulated in six subtypes of monkey vascular cells during aging. Targeted inactivation of FOXO3A in human vascular endothelial cells recapitulates the major phenotypic defects observed in aged monkey arteries, verifying FOXO3A loss as a key driver for arterial endothelial aging. Our study provides a critical resource for understanding the principles underlying primate arterial aging and contributes important clues to future treatment of age-associated vascular disorders.

Date: 2020
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DOI: 10.1038/s41467-020-15997-0

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